¡Ay! ¡Mi Estómago! ("Oh! My Stomach!" Translated to English) is a medicine that appeared in The Getaway that according to Greg says either cures or causes diarrhea. The Heffley family bought it when Frank was having stomach problems due to the microbes in the water at Isla de Corales.
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The packaging for the medicine.
Frank in the bathroom with the family waiting outside after he consumed the medicine.